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Copegus is used to treat chronic hepatitis C which is a disease of the liver. It helps the immune system fight the hepatitis C virus, and make it harder for the virus to reproduce within the body.
Common useCopegus is used together with an interferon (such as PegIntron or Intron A) to treat chronic hepatitis C which is a disease of the liver. This is a drug for the patients who have not been treated with interferon previously or who have had a return of hepatitis C following successful treatment with interferon. It helps the immune system fight the hepatitis C virus, and make it harder for the virus to reproduce within the body. Copegus belongs to the antivirals.
Dosage and directionThe usual dose of Copegus per day is 800 mg, 1,000 mg, or 1,200 mg i orally in two divided doses (morning and evening) with food for 24 or 48 weeks. The dose and duration of treatment depend on your condition, on body weight, on baseline disease characteristics, response to therapy and tolerability of the regimen. Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. It should be taken consistently. For example, it should be taken at the same time or times each day and each time.
PrecautionsCopegus may decrease the number of red blood cells in your body (anemia) and it can be life-threatening in people who have heart disease or circulation problems. Careful consideration is advised if Copegus is used in patients with heart or circulation problems since the anemia may aggravate these conditions. Your blood will need to be tested often. Also your vision, liver function and thyroid function may also need to be tested. Visit your doctor regularly. Call your doctor at once if you have pale or yellowed skin, dark colored urine, fever, confusion, chest pain, weakness, or trouble breathing. Copegus may cause birth defects and/or death in unborn babies that are exposed to it during pregnancy. If you or your sexual partner are or may be pregnant, do not take Copegus, and contact your doctor immediately. Women and men who are taking Copegus must avoid pregnancy during treatment with this drug and for 6 months after this medication has been stopped. Consult your doctor or pharmacist for more information.
ContraindicationsBefore taking Copegus you should talk with your doctor if you are allergic to peginterferon alfa-2a, any other interferon, ribavirin, polyethylene glycol, or to any of the ingredients of the medication, if you are an infant, breast-feeding, pregnant or has a pregnant partner. Also in the way if you have decompensated liver disease, hemoglobinopathies (thalassemia, sickle-cell anemia), HIV-HCV (human immunodeficiency virus and hepatitis C virus) with cirrhosis and a baseline Child-Pugh score greater than or equal to 6. And you should discuss with your doctor if you have a severe psychiatric disorder, autoimmune diseases (including autoimmune hepatitis), thyroid problems not controlled by medication even in the past.
Drug interactionsIf Copegus is used with other antiviral drugs with similar mechanisms of action it may cause a condition in which lactic acid accumulates in the blood (lactic acidosis). This situation can lead to serious medical problems. Also do not take Copegus with antiviral drugs that used to manage HIV infection (zidovudine (Retrovir), zalcitabine (Hivid) or stavudine (Zerit)).
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